Sanes is Professor in the Center for Neural Science and Department of Biology at New York University. Named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010 for his research in auditory central nervous system development, his research has been supported by the National Institute on Deafness and Other Communication Disorders and the National Science Foundation.

Development of the Nervous System presents a broad and basic treatment of the established and evolving principles of neural development as exemplified by key experiments and observations from past and recent times. The text is organized ontogenically. Immo killer v110 download pc. It begins with the emergence of the neural primordium and takes a chapter-by-chapter approach in succeeding events in neural development: patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, neuron survival and death, synapse formation and developmental plasticity. Finally, in the last chapter, with the construction phase nearing completion, we examine the emergence of behavior. This new edition reflects the complete modernization of the field that has been achieved through the intensive application of molecular, genetic, and cell biological approaches. It is richly illustrated with color photographs and original drawings. Combined with the clear and concise writing, the illustrations make this a book that is well suited to students approaching this intriguing field for the first time.

Key Features. Neural induction Development and evolution of neurons Early embryology of metazoans Derivation of neural tissue Interactions with neighboring tissues in making neural tissue The molecular nature of the neural inducer Conservation of neural induction Interactions among the ectodermal cells in controlling neuroblast segregation Summary 2. Polarity and segmentation Regional identity of the nervous system The anterior–posterior axis and hox genes Hox gene function in the vertebrate nervous system Signaling molecules that pattern the anterior–posterior axis in vertebrates: heads or tails Organizing centers in the developing brain Forebrain development, prosomeres, and pax genes Dorsal–ventral polarity in the neural tube Dorsal neural tube and neural crest Patterning the cerebral cortex Summary 3. Genesis and migration What determines the number of cells produced by the progenitors? The generation of neurons and glia Cerebral cortex histogenesis Cerebellar cortex histogenesis Molecular mechanisms of neuronal migration Postembryonic and adult neurogenesis Summary 4.

Determination and differentiation Transcriptional hierarchies in invariant lineages: C. Elegans neurons Spatial and temporal coordinates of determination: drosophila CNS neuroblasts Asymmetric cell divisions and asymmetric fate Generating complexity through cellular interactions: the drosophila retina Specification and differentiation through cellular interactions and interactions with the local environment: the vertebrate neural crest Competence and histogenesis: the mammalian cortex The interplay of intrinsic and extrinsic influences in histogenesis: the vertebrate retina Interpreting gradients and the spatial organization of cell types: spinal motor neurons Summary 5. Axon growth and guidance The growth cone The dynamic cytoskeleton Dendrite formation What do growth cones grow on? What provides directional information to growth cones? Cell adhesion and labeled pathways Repulsive guidance Chemotaxis, gradients, and local information Signal transduction The midline: to cross or not to cross? Attraction and repulsion: desensitization and adaptation The optic pathway: getting there from here Summary 6. Target selection Defasciculation Target recognition and target entry Slowing down and branching in the target region Border patrol: the prevention of inappropriate targeting Topographic mapping Chemospecificity and ephrins The third dimension, lamina-specific termination Cellular and synaptic targeting Sniffing out targets Shifting and fine tuning of connections Summary 7.